Titans vs. Colts NFL Game Week 2 | Sep 21, 2025

The Tennessee Titans and Indianapolis Colts are set to ignite their AFC South rivalry in a crucial Week 3 matchup of the 2025 NFL season. Scheduled for Sunday, September 21, 2025, at 12:00 PM ET, this game at Lucas Oil Stadium in Indianapolis, Indiana, promises a fierce battle between two teams vying for early divisional supremacy. Broadcast on CBS, with tickets starting at an incredibly affordable $28, fans have a prime opportunity to witness this intense rivalry live or tune in from home. This clash blends young talent, strategic coaching, and the passionate energy of two dedicated fanbases. Here’s a comprehensive guide to the game, including team dynamics, key players, viewing options, and tips for attending or watching.

A Storied AFC South Rivalry

The Titans-Colts rivalry is one of the NFL’s most competitive, with Indianapolis holding a 36-22 edge in the all-time series. Recent matchups have been tightly contested, with the Titans winning three of the last five games, including a 24-17 victory in 2024. This Week 3 game offers the Titans, who finished 6-11 in 2024 under new head coach Brian Callahan, a chance to build momentum with young quarterback Will Levis. Meanwhile, the Colts, coming off a 9-8 season in 2024 under Shane Steichen, aim to leverage their explosive offense led by Anthony Richardson to assert control in the AFC South.

Both teams are driven by playoff aspirations. The Titans are rebuilding around a new offensive identity, while the Colts are looking to capitalize on their young core and veteran additions to make a postseason push. This early-season matchup could shape the divisional race and set the tone for the rest of 2025.

Game Details: When, Where, and How to Watch

• Date and Time: Sunday, September 21, 2025, at 12:00 PM ET
• Location: Lucas Oil Stadium, Indianapolis, Indiana
• TV/Streaming: CBS (check local listings for channel numbers)
• Local Broadcast: WTVF (CBS/5) in Nashville, WTTV (CBS/4) in Indianapolis
• Radio: WGFX 104.5 FM (Nashville), WFNI 107.5 FM (Indianapolis), SiriusXM channels 243 (Tennessee) and 244 (Indianapolis)
• Announcers: Spero Dedes (play-by-play), Adam Archuleta (color analyst), Aditi Kinkhabwala (sideline)
• Streaming Options: Stream the game via Paramount+, the CBS Sports app, fuboTV, or YouTube TV, all offering free trials for new users. NFL+ provides mobile streaming for out-of-market fans, starting at $6.99/month.

CBS’s broadcast, featuring Spero Dedes’s engaging play-by-play and Adam Archuleta’s expert analysis, delivers a high-quality viewing experience. Fans can stream the game through Paramount+ or the CBS Sports app with a cable login or via live TV streaming services like fuboTV, which offers a seven-day free trial. NFL+ is perfect for out-of-market viewers, providing live game audio and mobile streaming. Check your local CBS affiliate to confirm channel availability, as it varies by region.

Ticket Information: Experience Lucas Oil Stadium

Attending the game at Lucas Oil Stadium, with its retractable roof and modern amenities, is an affordable and exciting option for NFL fans, with tickets starting at just $28 through platforms like Ticketmaster, StubHub, and SeatGeek. Prices vary based on seating location, with upper-level seats in sections like 600-645 offering budget-friendly options and lower-level seats near the 50-yard line commanding higher rates. Given the rivalry’s intensity and the low ticket prices, demand is expected to be high, so fans should act quickly.

To secure the best deals, compare prices across platforms and opt for verified tickets to avoid scams. Enhance your game-day experience with Titans or Colts gear from Fanatics, offering everything from Will Levis jerseys to Anthony Richardson hoodies. Lucas Oil Stadium’s vibrant atmosphere, complete with the “Sweet Caroline” sing-along and Colts’ pregame traditions, makes this a must-attend event for football fans.

Key Players to Watch

Tennessee Titans

• Will Levis (QB): The second-year quarterback showed promise in 2024, throwing for 2,842 yards, 16 touchdowns, and nine interceptions. His strong arm and mobility will test Indianapolis’s secondary.
• Tony Pollard (RB): Pollard led the Titans with 1,064 rushing yards and seven touchdowns in 2024, while adding 298 receiving yards. His speed could exploit gaps in the Colts’ run defense.
• Calvin Ridley (WR): Ridley, acquired in 2024, had 76 catches for 1,012 yards and six touchdowns. His route-running precision will challenge Indianapolis’s cornerbacks.
• Jeffery Simmons (DT): The defensive star recorded 8.5 sacks and 44 tackles in 2024. His ability to disrupt the Colts’ offensive line will be key.

Indianapolis Colts

• Anthony Richardson (QB): The 2023 first-round pick threw for 2,671 yards, 15 touchdowns, and eight interceptions in 2024, while rushing for 612 yards and six scores. His dual-threat ability makes him a matchup nightmare.
• Jonathan Taylor (RB): Taylor ran for 1,387 yards and 11 touchdowns in 2024, ranking fifth in the NFL. His physicality will test Tennessee’s front seven.
• Michael Pittman Jr. (WR): Pittman led the Colts with 81 catches for 1,082 yards and seven touchdowns in 2024. His reliability will challenge Tennessee’s secondary.
• Shane Steichen (Head Coach): Steichen’s creative play-calling led to a top-10 offense (366.2 yards per game) in 2024. His schemes to maximize Richardson’s versatility will be crucial.

Game Preview: What to Expect on the Field

This matchup features two young quarterbacks and physical, run-heavy offenses. The Titans’ offense, ranked 16th in scoring (21.8 points per game in 2024), relies on Pollard’s explosiveness and Levis’s deep-ball accuracy. Their defense, 12th in yards allowed (324.9 per game), is anchored by Simmons and linebacker Harold Landry (9.5 sacks in 2024), excelling at pressuring quarterbacks.

The Colts’ offense, ranked seventh in scoring (25.4 points per game in 2024), thrives on Richardson’s dual-threat ability and Taylor’s dominance. Their defense, 15th in points allowed (21.6 per game), features playmakers like DeForest Buckner (7.5 sacks) and Kenny Moore II (three interceptions). Key battles to watch include:

• Titans’ O-line vs. Colts’ D-line: Indianapolis’s Buckner and Kwity Paye will target Tennessee’s tackles to disrupt Levis’s pocket presence.
• Michael Pittman Jr. vs. L’Jarius Sneed: Tennessee’s top corner (two interceptions in 2024) must contain Pittman to limit Indianapolis’s passing attack.
• Red Zone Efficiency: Indianapolis’s 58.6% red zone touchdown rate (ninth in NFL) faces Tennessee’s 50.3% red zone defense (seventh in NFL).

Lucas Oil Stadium’s indoor setting ensures ideal conditions, favoring both teams’ passing games and setting the stage for a competitive, high-scoring affair.

Viewing Experience: CBS’s Sunday Afternoon Broadcast

CBS’s broadcast, with Spero Dedes, Adam Archuleta, and Aditi Kinkhabwala, offers a dynamic viewing experience, blending engaging commentary with sideline insights. The CBS Sports app enhances the experience with live stats, player tracking, and multi-angle replays. Local viewers in Nashville and Indianapolis can tune into WTVF or WTTV, while streaming services like Paramount+ and YouTube TV provide flexibility for cord-cutters. NFL+ is perfect for out-of-market fans, offering live audio and mobile streaming.

To optimize your viewing, test your streaming setup in advance and ensure a stable internet connection for HD quality. Pair your watch party with game-day snacks like Nashville hot chicken or Indy-style pork tenderloin sandwiches to capture the rivalry’s vibe.

Why This Game Matters

This Week 3 clash is a pivotal early test in the AFC South race. A Titans win would signal their rebuilding efforts are gaining traction and boost their divisional standing. For the Colts, a victory would reinforce their status as playoff contenders and provide momentum in a competitive division. The game also showcases two passionate fanbases, with Tennessee’s “Titan Up” spirit and Indianapolis’s “Colts Strong” energy adding to the intensity.

Fan Tips: How to Prepare

• Get Your Gear: Show your team pride with Titans or Colts apparel from Fanatics. From Will Levis jerseys to Jonathan Taylor hoodies, there’s gear for every fan.
• Watch Party Setup: Set up your Paramount+ or CBS Sports app early to avoid technical issues. A large screen and surround sound can elevate the experience.
• Stay Connected: Follow @Titans and @Colts on social media for pregame content, live updates, and highlights. The NFL app offers real-time stats and exclusive content.
• Betting Insights: Per FanDuel, the Colts are favored at -145, with the Titans at +120. The over/under is set at 46.5 points, suggesting a competitive, moderate-scoring game.

The Titans vs. Colts Week 3 matchup is a must-watch AFC South showdown, blending young quarterbacks, physical play, and divisional stakes. Whether you’re cheering from Lucas Oil Stadium or watching on CBS, this game promises intense action and unforgettable moments. Secure your tickets, don your team colors, and get ready for a Sunday afternoon filled with NFL excitement.