Seahawks at 49ers: Key Injuries, Depth Charts, and Final Score Forecast

NFC West Rivals Meet in Preseason Test of Depth and Development

As the NFL Preseason Week 1 heats up on Sunday, September 7, 2025, all eyes will turn to one of the league’s fiercest rivalries: 🏈 Seahawks at 49ers. The action kicks off at 1:05 PM ET from Levi’s Stadium in Santa Clara, California. Although the game doesn’t count in the standings, it will provide a first look at how two of the NFC’s top programs are shaping up for the regular season.

From quarterback competitions to new rookie sensations, updated depth charts, and a look at key injuries, the 🏈 Seahawks at 49ers matchup is rich with storylines that matter—especially for fans eager to assess talent and momentum heading into 2025.

Let’s dive deep into the roster news, injuries, players to watch, and a bold final score forecast for this exciting West Coast preseason clash.

📅 Game Overview

• Matchup: 🏈 Seahawks at 49ers
• Date: Sunday, September 7, 2025
• Time: 1:05 PM ET
• Location: Levi’s Stadium, Santa Clara, CA
• TV Broadcast: FOX (Regional), NFL Network (National)
• Streaming: NFL+, YouTube TV, Hulu + Live, fuboTV
• Radio: KIRO 710 AM (Seattle) | KNBR 680 AM (San Francisco)
• Tickets: as low as $228

🐦 Seattle Seahawks: Geno Smith Leads New-Look Offense

The Seattle Seahawks enter the 2025 preseason with elevated expectations under second-year head coach Mike Macdonald. Quarterback Geno Smith remains the starter, but the team has focused on rebuilding the offensive line and reenergizing the defense.

Key Seahawks Storylines

• Geno Smith’s Command: Smith is expected to play a series or two, giving way to Sam Howell and rookie Aidan Burke.
• Offensive Line Battles: With Charles Cross and Abraham Lucas returning, the spotlight shifts to guard and center competitions.
• Rookie Watch: First-round pick WR Tyson Drew brings game-breaking speed and could shine early.
• Defensive Identity Shift: Look for more blitz-heavy, versatile packages as Seattle adapts to Macdonald’s aggressive scheme.

🟥 San Francisco 49ers: Reloading for Another NFC Title Run

The 49ers have a loaded roster but must use the preseason to evaluate depth and develop young contributors. With Brock Purdy entering Year 3, the team has Super Bowl aspirations once again.

Key 49ers Storylines

• Quarterback Rotation: Expect Sam Darnold to get the start with Rookie QB Tyler Grayson seeing extensive action.
• Brandon Aiyuk Contract Talks: While unlikely to play, Aiyuk’s holdout casts a shadow over camp.
• RB Depth Chart Watch: Christian McCaffrey is expected to sit; Jordan Mason and rookie Keon White will get valuable reps.
• Defensive Front Depth: Even without Nick Bosa, the 49ers’ front is lethal. Watch Drake Jackson and Rookie DE Zach Tate.

⚕️ Key Injuries – 🏈 Seahawks at 49ers

Seattle Seahawks Injury Report

• Kenneth Walker III (RB) – Out (ankle)
• Devon Witherspoon (CB) – Day-to-day (hamstring)
• Noah Fant (TE) – Questionable (knee)
• Damien Lewis (G) – Out (personal)
• D’Wayne Eskridge (WR) – IR (foot)

San Francisco 49ers Injury Report

• Brandon Aiyuk (WR) – Holdout (contract)
• Christian McCaffrey (RB) – DNP (rest)
• Fred Warner (LB) – Out (groin)
• Elijah Mitchell (RB) – Questionable (shoulder)
• Talanoa Hufanga (S) – IR (ACL recovery)

📊 Projected Depth Charts – 🏈 Seahawks at 49ers

Seattle Seahawks (Preseason 1st Team)

Offense:
QB: Geno Smith
RB: Zach Charbonnet
WR: DK Metcalf, Tyler Lockett, Tyson Drew
TE: Colby Parkinson
OL: Cross, Haynes, Oluwatimi, Bradford, Lucas

Defense:
DL: Dre’Mont Jones, Jarran Reed, Mario Edwards
EDGE: Boye Mafe, Uchenna Nwosu
LB: Jordyn Brooks, Devin Bush
CB: Tre Brown, Michael Jackson
S: Julian Love, Quandre Diggs

San Francisco 49ers (Preseason 1st Team)

Offense:
QB: Sam Darnold
RB: Jordan Mason
WR: Deebo Samuel, Jauan Jennings, Ronnie Bell
TE: George Kittle
OL: Williams, Banks, Brendel, Burford, McKivitz

Defense:
DL: Armstead, Kinlaw, Jackson, Tate
LB: Greenlaw, Flanagan-Fowles
CB: Charvarius Ward, Lenoir
S: Ji’Ayir Brown, George Odum

🔥 Players to Watch

Seahawks

• Tyson Drew (WR) – Can stretch the field and challenge secondaries with elite speed.
• Sam Howell (QB) – Looking to solidify himself as QB2.
• Cam Young (DT) – Young defensive lineman with breakout potential.
• Jerrick Reed II (S) – Expected to get reps with the first unit due to injuries.

49ers

• Tyler Grayson (QB) – Third-round rookie from USC with a strong arm and poise.
• Keon White (RB) – A shifty rookie who could become the RB2 by Week 1.
• Zach Tate (DE) – First-round pick who’ll likely rotate in with the starters.
• Ronnie Bell (WR) – Underrated playmaker trying to crack WR3 territory.

🎯 Bold Predictions for 🏈 Seahawks at 49ers

1. Tyson Drew Will Score a 50+ Yard Touchdown
   Seattle’s rookie WR has the speed to take the top off defenses, even against San Francisco’s backups.
2. Tyler Grayson Outperforms Expectations
   The rookie QB will complete 10+ passes and lead a TD drive late in the second quarter.
3. Seattle’s Pass Rush Records 5 Sacks
   Mike Macdonald’s exotic fronts will confuse San Francisco’s second-string O-line.
4. Turnovers Shape the Game
   Expect at least 3 total turnovers, including a pick-six by Seahawks CB Coby Bryant.
5. Final Score Decided in Final Minutes
   This will be a back-and-forth affair that goes down to the wire.

💸 Betting Odds & Final Score Forecast

Spread: 49ers -3
Over/Under: 37.5
Moneyline: Seahawks +120, 49ers -140

Preseason betting trends lean toward home teams, especially those with deeper second units. However, Seattle’s young roster has energy and speed, giving them a real shot.

🧠 Final Score Prediction:

Seahawks 24, 49ers 20

• MVP: Tyson Drew – 4 catches, 98 yards, 1 TD
• Surprise Performer: Zach Tate – 1.5 sacks
• X-Factor: Sam Howell’s second-half poise

🏟️ Game Day Info – Levi’s Stadium

Located in Santa Clara, Levi’s Stadium is known for its state-of-the-art design and sun-soaked games.

• Weather Forecast: Sunny, 84°F
• Gates Open: 11:00 AM PT
• Concessions: BBQ pork sliders, garlic fries, and local craft beer
• Fan Experiences: Autograph tents, VR football sim, new 2025 jersey shop

🧪 What to Watch For

Quarterback Play

How do Howell and Grayson respond under pressure? Their growth could determine their future with each team.

Rookie Impact

Between Tyson Drew, Keon White, and Zach Tate, this game will showcase the next generation of NFL stars.

Coaching Styles

Mike Macdonald’s debut as Seahawks head coach against the seasoned Kyle Shanahan adds layers of intrigue.

📺 How to Watch 🏈 Seahawks at 49ers Live

TV Broadcast:

• FOX (regional)
• NFL Network (national)

Streaming Platforms:

• NFL+
• YouTube TV
• Hulu + Live TV
• fuboTV

Radio Broadcast:

• Seattle: KIRO 710 AM
• San Francisco: KNBR 680 AM

📌 Final Thoughts – Why This Game Matters

The 🏈 Seahawks at 49ers preseason matchup is more than a warm-up. It’s a showcase of depth, development, and early indications of team identity heading into the 2025 season. With rookies ready to burst onto the scene and backups fighting for a role, fans can expect a high-energy game filled with unpredictability, strategy, and moments of brilliance.

Whether it’s Booming TDs from rookies, breakout performances from surprise contributors, or coaching chess matches, this NFC West clash is must-watch preseason action.