Coming off a dominant 31-10 win over the reigning champion Los Angeles Rams, the Bills head home to host the Tennessee Titans, who lost 21-20 to the New York Giants in Week 1 after kicker Randy Bullock missed a 47-yard field goal with four seconds left in the fourth quarter.

The Bills’ eye-opening victory over the Rams coupled with the Titans’ shocking loss to the Giants illustrates two playoff squads from the previous season headed in opposite directions. …

“The Bills looked good against the defending champs in Week 1, while the Titans are coming off a tough loss to the Giants. Ryan Tannehill is still the signal-caller in Tennessee, and that’s reason enough to lean toward Buffalo with the spread. I’m not sure the Titans will be able to keep up and score with the Bills offense. Give me the favorites here -10.”

Prediction: Bills 38, Titans 22