Thursday, November 10, 2022
| AWAY | HOME | RESULT |
| Atlanta | Carolina | CAR 25 – ATL 15 |
Sunday, November 13, 2022
| AWAY | HOME | RESULT |
| Seattle | Tampa Bay | TB 21 – SEA 16 |
| Denver | Tennessee | TEN 17 – DEN 10 |
| Cleveland | Miami | MIA 39 – CLE 17 |
| Detroit | Chicago | DET 31 – CHI 30 |
| Houston | N.Y. Giants | NYG 24 – HOU 16 |
| Jacksonville | Kansas City | KC 27 – JAC 17 |
| Minnesota | Buffalo | MIN 33 – BUF 30 / OT |
| New Orleans | Pittsburgh | PIT 20 – NO 10 |
| Indianapolis | Las Vegas | IND 25 – LV 20 |
| Arizona | L.A. Rams | ARI 27 – LAR 17 |
| Dallas | Green Bay | GB 31 – DAL 28 / OT |
| L.A. Chargers | San Francisco | SF 22 – LAC 16 |
