Thursday, November 11, 2021
| Matchup | Result |
|---|---|
| Baltimore @ Miami | MIA 22 – BAL 10 |
Sunday, November 14, 2021
| Matchup | Result |
|---|---|
| Atlanta @ Dallas | DAL 43 – ATL 3 |
| Jacksonville @ Indianapolis | IND 23 – JAC 17 |
| Cleveland @ New England | NE 45 – CLE 7 |
| Buffalo @ NY Jets | BUF 45 – NYJ 17 |
| Detroit @ Pittsburgh | DET 16 – PIT 16 / OT |
| New Orleans @ Tennessee | TEN 23 – NO 21 |
| Tampa Bay @ Washington | WAS 29 – TB 19 |
| Carolina @ Arizona | CAR 34 – ARI 10 |
| Minnesota @ LA Chargers | MIN 27 – LAC 20 |
| Philadelphia @ Denver | PHI 30 – DEN 13 |
| Seattle @ Green Bay | GB 17 – SEA 0 |
| Kansas City @ Las Vegas | KC 41 – LV 14 |
Monday, November 15, 2021
| Matchup | Result |
|---|---|
| LA Rams @ San Francisco | SF 31 – LAR 10 |
