Thursday, November 24, 2022
| AWAY | HOME | RESULT |
| Buffalo | Detroit | BUF 28 – DET 25 |
| N.Y. Giants | Dallas | DAL 28 – NYG 20 |
| New England | Minnesota | MIN 33 – NE 26 |
Sunday, November 27, 2022
| AWAY | HOME | RESULT |
| Atlanta | Washington | WAS 19 – ATL 13 |
| Baltimore | Jacksonville | JAC 28 – BAL 27 |
| Chicago | N.Y. Jets | NYJ 31 – CHI 10 |
| Cincinnati | Tennessee | CIN 20 – TEN 16 |
| Denver | Carolina | CAR 23 – DEN 10 |
| Houston | Miami | MIA 30 – HOU 15 |
| Tampa Bay | Cleveland | CLE 23 – TB 17 / OT |
| L.A. Chargers | Arizona | LAC 25 – ARI 24 |
| Las Vegas | Seattle | LV 40 – SEA 34 / OT |
| L.A. Rams | Kansas City | KC 26 – LAR 10 |
| New Orleans | San Francisco | SF 13 – NO 0 |
| Green Bay | Philadelphia | PHI 40 – GB 33 |
Monday, November 28, 2022
| AWAY | HOME | RESULT |
| Pittsburgh | Indianapolis | PIT 24 – IND 17 |
