Thursday, November 25, 2021
| Matchup | Result |
|---|---|
| Chicago at Detroit | CHI 16 @ DET 14 |
| Las Vegas at Dallas | LV 36 @ DAL 33 / OT |
| Buffalo at New Orleans | BUF 31 @ NO 6 |
Sunday, November 28, 2021
| Matchup | Tickets |
|---|---|
| Pittsburgh at Cincinnati | CIN 41 @ PIT 10 |
| NY Jets at Houston | NYJ 21 @ HOU 14 |
| Tampa Bay at Indianapolis | TB 38 @ IND 31 |
| Atlanta at Jacksonville | ATL 21 @ JAC 14 |
| Carolina at Miami | MIA 33 @ CAR 10 |
| Tennessee at New England | NE 36 @ TEN 13 |
| Philadelphia at NY Giants | NYG 13 @ PHI 7 |
| LA Chargers at Denver | DEN 28 @ LAC 13 |
| LA Rams at Green Bay | GB 36 @ LAR 28 |
| Minnesota at San Francisco | SF 34 @ MIN 26 |
| Cleveland at Baltimore | BAL 16 @ CLE 10 |
Monday, November 29, 2021
| Matchup | Result |
|---|---|
| Seattle @ Washington | WAS 17 @ SEA 15 |
