Thursday, December 1, 2022
| AWAY | HOME | RESULT |
| Buffalo | New England | BUF 24 – NE 10 |
Sunday, December 4, 2022
| AWAY | HOME | RESULT |
| Cleveland | Houston | CLE 27 – HOU 14 |
| Denver | Baltimore | BAL 10 – DEN 9 |
| Green Bay | Chicago | GB 28 – CHI 19 |
| Jacksonville | Detroit | DET 40 – JAC 14 |
| N.Y. Jets | Minnesota | MIN 27 – NYJ 22 |
| Pittsburgh | Atlanta | PIT 19 – ATL 16 |
| Tennessee | Philadelphia | PHI 35 – TEN 10 |
| Washington | N.Y. Giants | WAS 20 – NYG 20 / OT |
| Miami | San Francisco | SF 33 – MIA 17 |
| Seattle | L.A. Rams | SEA 27 – LAR 23 |
| Kansas City | Cincinnati | CIN 27 – KC 24 |
| L.A. Chargers | Las Vegas | LV 27 – LAC 20 |
| Indianapolis | Dallas | DAL 54 – IND 19 |
Monday, December 5, 2022
| AWAY | HOME | RESULT |
| New Orleans | Tampa Bay | TB 17 – NO 16 |
