Thursday, December 8, 2022
| AWAY | HOME | RESULT |
| Las Vegas | L.A. Rams | LAR 17 – LV 16 |
Sunday, December 11, 2022
| AWAY | HOME | RESULT |
| Cleveland | Cincinnati | CIN 23 – CLE 10 |
| Baltimore | Pittsburgh | BAL 16 – PIT 14 |
| Houston | Dallas | DAL 27 – HOU 23 |
| Jacksonville | Tennessee | JAC 36 – TEN 22 |
| Minnesota | Detroit | DET 34 – MIN 23 |
| N.Y. Jets | Buffalo | BUF 20 – NYJ 12 |
| Philadelphia | N.Y. Giants | PHI 48 – NYG 22 |
| Kansas City | Denver | KC 34 – DEN 28 |
| Carolina | Seattle | CAR 30 – SEA 24 |
| Tampa Bay | San Francisco | SF 35 – TB 7 |
| Miami | L.A. Chargers | LAC 23 – MIA 17 |
Monday, December 12, 2022
| AWAY | HOME | RESULT |
| New England | Arizona | NE 27 – ARI 13 |
