Thursday, December 15, 2022
| AWAY | HOME | RESULT |
| San Francisco | Seattle | SF 21 – SEA 13 |
Saturday, December 17, 2022
| AWAY | HOME | RESULT |
| Indianapolis | Minnesota | MIN 39 – IND 36 / OT |
| Baltimore | Cleveland | CLE 13 – BAL 3 |
| Miami | Buffalo | BUF 32 – MIA 29 |
Sunday, December 18, 2022
| AWAY | HOME | RESULT |
| Atlanta | New Orleans | NO 21 – ATL 18 |
| Dallas | Jacksonville | JAC 40 – DAL 34 / OT |
| Detroit | N.Y. Jets | DET 20 – NYJ 17 |
| Kansas City | Houston | KC 30 – HOU 24 / OT |
| Philadelphia | Chicago | PHI 25 – CHI 20 |
| Pittsburgh | Carolina | PIT 24 – CAR 16 |
| Arizona | Denver | DEN 24 – ARI 15 |
| New England | Las Vegas | LV 30 – NE 24 |
| Cincinnati | Tampa Bay | CIN 34 – TB 23 |
| Tennessee | L.A. Chargers | LAC 17 – TEN 14 |
| N.Y. Giants | Washington | NYG 20 – WAS 12 |
Monday, December 19, 2022
| AWAY | HOME | RESULT |
| L.A. Rams | Green Bay | GB 24 – LAR 12 |
