Thursday, December 22, 2022
| AWAY | HOME | RESULT |
| Jacksonville | N.Y. Jets | JAC 19 – NYJ 3 |
Saturday, December 24, 2022
| AWAY | HOME | RESULT |
| Atlanta | Baltimore | BAL 17 – ATL 9 |
| Buffalo | Chicago | BUF 35 – CHI 13 |
| Cincinnati | New England | CIN 22 – NE 18 |
| Detroit | Carolina | CAR 37 – DET 23 |
| New Orleans | Cleveland | NO 17 – CLE 10 |
| N.Y. Giants | Minnesota | MIN 27 – NYG 24 |
| Seattle | Kansas City | KC 24 – SEA 10 |
| Houston | Tennessee | HOU 19 – TEN 14 |
| Washington | San Francisco | SF 37 – WAS 20 |
| Philadelphia | Dallas | DAL 40 – PHI 34 |
| Las Vegas | Pittsburgh | PIT 13 – LV 10 |
Sunday, December 25, 2022
| AWAY | HOME | RESULT |
| Green Bay | Miami | GB 26 – MIA 20 |
| Denver | L.A. Rams | LAR 51 – DEN 14 |
| Tampa Bay | Arizona | TB 19 – ARI 16 / OT |
Monday, December 26, 2022
| AWAY | HOME | RESULT |
| L.A. Chargers | Indianapolis | LAC 20 – IND 3 |
