Saturday, January 7, 2023
| AWAY | HOME | RESULT |
| Kansas City | Las Vegas | KC 31 – LV 13 |
| Tennessee | Jacksonville | JAC 20 – TEN 16 |
Sunday, January 8, 2023
| AWAY | HOME | RESULT |
| Baltimore | Cincinnati | CIN 27 – BAL 16 |
| Carolina | New Orleans | CAR 10 – NO 7 |
| Cleveland | Pittsburgh | PIT 28 – CLE 14 |
| Houston | Indianapolis | HOU 32 – IND 31 |
| Minnesota | Chicago | MIN 29 – CHI 13 |
| New England | Buffalo | BUF 35 – NE 23 |
| N.Y. Jets | Miami | MIA 11 – NYJ 6 |
| Tampa Bay | Atlanta | ATL 30 – TB 17 |
| Arizona | San Francisco | SF 38 – ARI 13 |
| Dallas | Washington | WAS 26 – DAL 6 |
| L.A. Chargers | Denver | DEN 31 – LAC 28 |
| L.A. Rams | Seattle | SEA 19 – LAR 16 / OT |
| N.Y. Giants | Philadelphia | PHI 22 – NYG 16 |
| Detroit | Green Bay | DET 20 – GB 16 |
