Thursday, September 15, 2022
| AWAY | HOME | RESULT |
| L.A. Chargers | Kansas City | KC 27 – LAC 24 |
Sunday, September 18, 2022
| AWAY | HOME | RESULT |
| Carolina | N.Y. Giants | NYG 19 – CAR 16 |
| Indianapolis | Jacksonville | JAC 24 – IND 0 |
| Miami | Baltimore | MIA 42 – BAL 38 |
| New England | Pittsburgh | NE 17 – PIT 14 |
| N.Y. Jets | Cleveland | NYJ 31 – CLE 30 |
| Tampa Bay | New Orleans | TB 20 – NO 10 |
| Washington | Detroit | DET 36 – WAS 27 |
| Atlanta | L.A. Rams | LAR 31 – ATL 27 |
| Seattle | San Francisco | SF 27 – SEA 7 |
| Arizona | Las Vegas | ARI 29 – LV 23 / OT |
| Cincinnati | Dallas | DAL 20 – CIN 17 |
| Houston | Denver | DEN 16 – HOU 9 |
| Chicago | Green Bay | GB 27 – CHI 10 |
Monday, September 19, 2022
| AWAY | HOME | RESULT |
| Tennessee | Buffalo | BUF 41 – TEN 7 |
| Minnesota | Philadelphia | PHI 24 – MIN 7 |
