Thursday, September 23, 2021
| Matchup | Result |
|---|---|
| Carolina @ Houston | CAR 24 @ HOU 9 |
Sunday, September 26, 2021
| Matchup | Result |
|---|---|
| Washington @ Buffalo | BUF 43 @ WAS 21 |
| Chicago @ Cleveland | CLE 26 @ CHI 6 |
| Baltimore @ Detroit | BAL 19 @ DET 17 |
| Arizona @ Jacksonville | ARI 31 @ JAC 19 |
| LA Chargers @ Kansas City | LAC 30 @ KC 24 |
| New Orleans @ New England | NO 28 @ NE 13 |
| Atlanta @ NY Giants | ATL 17 @ NYG 14 |
| Cincinnati @ Pittsburgh | CIN 24 @ PIT 10 |
| Indianapolis @ Tennessee | TEN 25 @ IND 16 |
| NY Jets @ Denver | DEN 26 @ NYJ 0 |
| Miami @ Las Vegas | LV 31 @ MIA 28 / OT |
| Tampa Bay @ LA Rams | LAR 34 @ TB 24 |
| Seattle @ Minnesota | MIN 30 @ SEA 17 |
| Green Bay @ San Francisco | GB 30 @ SF 28 |
Monday, September 27, 2021
| Matchup | Result |
|---|---|
| Philadelphia @ Dallas | DAL 41 @ PHI 21 |
