Thursday, September 22, 2022
| AWAY | HOME | RESULT |
| Pittsburgh | Cleveland | CLE 29 – PIT 17 |
Sunday, September 25, 2022
| AWAY | HOME | RESULT |
| Baltimore | New England | BAL 37 – NE 26 |
| Buffalo | Miami | MIA 21 – BUF 19 |
| Cincinnati | N.Y. Jets | CIN 27 – NYJ 12 |
| Detroit | Minnesota | MIN 28 – DET 24 |
| Houston | Chicago | CHI 23 – HOU 20 |
| Kansas City | Indianapolis | IND 20 – KC 17 |
| Las Vegas | Tennessee | TEN 24 – LV 22 |
| New Orleans | Carolina | CAR 22 – NO 14 |
| Philadelphia | Washington | PHI 24 – WAS 8 |
| Jacksonville | L.A. Chargers | JAC 38 – LAC 10 |
| Atlanta | Seattle | ATL 27 – SEA 23 |
| Green Bay | Tampa Bay | GB 14 – TB 12 |
| L.A. Rams | Arizona | LAR 20 – ARI 12 |
| San Francisco | Denver | DEN 11 – SF 10 |
Monday, September 26, 2022
| AWAY | HOME | RESULT |
| Dallas | N.Y. Giants | DAL 23 – NYG 16 |
