Thursday, September 29, 2022
| AWAY | HOME | RESULT |
| Miami | Cincinnati | CIN 27 – MIA 15 |
Sunday, October 2, 2022
| AWAY | HOME | RESULT |
| Minnesota | New Orleans | MIN 28 – NO 25 |
| Chicago | N.Y. Giants | NYG 20 – CHI 12 |
| Buffalo | Baltimore | BUF 23 – BAL 20 |
| Cleveland | Atlanta | ATL 23 – CLE 20 |
| Jacksonville | Philadelphia | PHI 29 – JAC 21 |
| L.A. Chargers | Houston | LAC 34 – HOU 24 |
| N.Y. Jets | Pittsburgh | NYJ 24 – PIT 20 |
| Seattle | Detroit | SEA 48 – DET 45 |
| Tennessee | Indianapolis | TEN 24 – IND 17 |
| Washington | Dallas | DAL 25 – WAS 10 |
| Arizona | Carolina | ARI 26 – CAR 16 |
| Denver | Las Vegas | LV 32 – DEN 23 |
| New England | Green Bay | GB 27 – NE 24 / OT |
| Kansas City | Tampa Bay | KC 41 – TB 31 |
Monday, October 3, 2022
| L.A. Rams | San Francisco | SF 24 – LAR 9 |
