Thursday, October 6, 2022
| AWAY | HOME | RESULT |
| Indianapolis | Denver | IND 12 – DEN 9 / OT |
Sunday, October 9, 2022
| AWAY | HOME | RESULT |
| N.Y. Giants | Green Bay | NYG 27 – GB 22 |
| Chicago | Minnesota | MIN 29 – CHI 22 |
| Atlanta | Tampa Bay | TB 21 – ATL 15 |
| Detroit | New England | NE 29 – DET 0 |
| Houston | Jacksonville | HOU 13 – JAC 6 |
| L.A. Chargers | Cleveland | LAC 30 – CLE 28 |
| Miami | N.Y. Jets | NYJ 40 – MIA 17 |
| Pittsburgh | Buffalo | BUF 38 – PIT 3 |
| Seattle | New Orleans | NO 39 – SEA 32 |
| Tennessee | Washington | TEN 21 – WAS 17 |
| San Francisco | Carolina | SF 37 – CAR 15 |
| Dallas | L.A. Rams | DAL 22 – LAR 10 |
| Philadelphia | Arizona | PHI 20 – ARI 17 |
| Cincinnati | Baltimore | BAL 19 – CIN 17 |
Monday, October 10, 2022
| AWAY | HOME | RESULT |
| Las Vegas | Kansas City | KC 30 – LV 29 |
