Thursday, October 13, 2022
| AWAY | HOME | RESULT |
| Washington | Chicago | WAS 12 – CHI 7 |
Sunday, October 16, 2022
| AWAY | HOME | RESULT |
| Cincinnati | New Orleans | CIN 30 – NO 26 |
| Baltimore | N.Y. Giants | NYG 24 – BAL 20 |
| Jacksonville | Indianapolis | IND 34 – JAC 27 |
| Minnesota | Miami | MIN 24 – MIA 16 |
| New England | Cleveland | NE 38 – CLE 15 |
| N.Y. Jets | Green Bay | NYJ 27 – GB 10 |
| San Francisco | Atlanta | ATL 28 – SF 14 |
| Tampa Bay | Pittsburgh | PIT 20 – TB 18 |
| Arizona | Seattle | SEA 19 – ARI 9 |
| Carolina | L.A. Rams | LAR 24 – CAR 10 |
| Buffalo | Kansas City | BUF 24 – KC 20 |
| Dallas | Philadelphia | PHI 26 – DAL 17 |
Monday, October 17, 2022
| AWAY | HOME | RESULT |
| Denver | L.A. Chargers | LAC 19 – DEN 16 / OT |
Notes
- Bye: Detroit, Houston, Las Vegas, Tennessee
- All times are US/Eastern.
