Thursday, October 20, 2022
| AWAY | HOME | RESULT |
| New Orleans | Arizona | ARI 42 – NO 34 |
Sunday, October 23, 2022
| AWAY | HOME | RESULT |
| Atlanta | Cincinnati | CIN 35 – ATL 17 |
| Cleveland | Baltimore | BAL 23 – CLE 20 |
| Detroit | Dallas | DAL 24 – DET 6 |
| Green Bay | Washington | WAS 23 – GB 21 |
| Indianapolis | Tennessee | TEN 19 – IND 10 |
| N.Y. Giants | Jacksonville | NYG 23 – JAC 17 |
| Tampa Bay | Carolina | CAR 21 – TB 3 |
| Houston | Las Vegas | LV 38 – HOU 20 |
| N.Y. Jets | Denver | NYJ 16 – DEN 9 |
| Kansas City | San Francisco | KC 44 – SF 23 |
| Seattle | L.A. Chargers | SEA 37 – LAC 23 |
| Pittsburgh | Miami | MIA 16 – PIT 10 |
Monday, October 24, 2022
| AWAY | HOME | RESULT |
| Chicago | New England | CHI 33 – NE 14 |
Notes
Bye: Buffalo, L.A. Rams, Minnesota, Philadelphia
All times are US/Eastern.
