Thursday, October 27, 2022
| AWAY | HOME | RESULT |
| Baltimore | Tampa Bay | BAL 27 – TB 22 |
Sunday, October 30, 2022
| AWAY | HOME | RESULT |
| Denver | Jacksonville | DEN 21 – JAC 17 |
| Arizona | Minnesota | MIN 34 – ARI 26 |
| Carolina | Atlanta | ATL 37 – CAR 34 / OT |
| Chicago | Dallas | DAL 49 – CHI 29 |
| Las Vegas | New Orleans | NO 24 – LV 0 |
| Miami | Detroit | MIA 31 – DET 27 |
| New England | N.Y. Jets | NE 22 – NYJ 17 |
| Pittsburgh | Philadelphia | PHI 35 – PIT 13 |
| Tennessee | Houston | TEN 17 – HOU 10 |
| N.Y. Giants | Seattle | SEA 27 – NYG 13 |
| San Francisco | L.A. Rams | SF 31 – LAR 14 |
| Washington | Indianapolis | WAS 17 – IND 16 |
| Green Bay | Buffalo | BUF 27 – GB 17 |
Monday, October 31, 2022
| AWAY | HOME | RESULT |
| Cincinnati | Cleveland | CLE 32 – CIN 13 |
Notes:
- Bye: Kansas City, L.A. Chargers
- All times are US/Eastern.
